In vitro inhibition of lipase, a-amylase, a-glucosidase, and angiotensin-converting enzyme by defatted rice bran extracts of red-pericarp rice mutant / (Record no. 148309)
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| 000 -LEADER | |
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| fixed length control field | 02888nab a22002657a 4500 |
| 850 ## - HOLDING INSTITUTION | |
| Holding institution | เอกสารภาษาไทย (ชั้น 5) |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190122b xxu||||| |||| 00| 0 eng d |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Repr.F18 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Chiou, Shiow-Ying. |
| 245 10 - TITLE STATEMENT | |
| Title | In vitro inhibition of lipase, a-amylase, a-glucosidase, and angiotensin-converting enzyme by defatted rice bran extracts of red-pericarp rice mutant / |
| author | Shiow-Ying Chiou ... [et.al.]. |
| 500 ## - GENERAL NOTE | |
| GENERAL NOTE | สนใจติดต่อขอรับบริการเอกสารฉบับเต็มที่ one stop service (สำนักหอสมุดฯ) หรือ e-mail ([email protected]) โทร. 0 2201 7254-56, 0 2201 7287-89 (จัดเก็บชั้น 5 - Repr.F18) |
| 518 ## - Year/Month of cataloging | |
| Year/Month | YJ2019 M02 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and objectives Freeze‐dried aqueous and various ethanolic (25%, 50%, 75%, and 95%) extracts of defatted red rice (mutant AM‐425) bran were prepared and designated as E0, E25, E50, E75, and E95, respectively. Phenolic constituents of extracts and the in vitro inhibitory effects of extracts against lipase, α‐amylase, α‐glucosidase, and angiotensin‐converting enzyme (ACE) were examined. Findings Yields of extracts ranged from 16.45% (E0) to 11.57% (E95). The E50 and E75 had higher total phenols (79.2-80.9 mg ferulic acid equivalent (FAE)/g extract) than other extracts. The E75 and E95 had higher total flavonoids (20.46-21.35 mg catechin equivalent/g extract). The most abundant phenolic acid and flavonoid were ferulic acid and catechin, respectively. Both E50 and E75 had higher inhibitory activity against lipase (IC50, 35.95-35.97 mg/ml), α‐amylase (IC50, 21.99-22.02 mg/ml), α‐glucosidase (IC50, 1.67 mg/ml), and ACE (IC50, 2.93-2.97 mg/ml). Conclusions Both E50 and E75 can be used to produce high‐value functional supplements. However, further studies with in vivo models reflecting potential human benefits are needed in the future. Significance and novelty The tested E50 and E75 had higher contents of total phenols. Moreover, both E50 and E75 were able to inhibit key enzymes relevant to obesity (lipase), type‐2 diabetes mellitus (α‐amylase and α‐glucosidase), and hypertension (angiotensin‐converting enzyme) in an in vitro model. The results suggest that defatted rice bran extracts could be considered as potential candidates for developing functional foods or supplements. |
| 648 ## - SUBJECT ADDED ENTRY--CHRONOLOGICAL TERM | |
| Chronological term | FOOD62M01 |
| 650 #0 - Subject-Topical Term | |
| Topical term or geographic name entry element | Angiotensin-converting enzyme. |
| 650 #0 - Subject-Topical Term | |
| Topical term or geographic name entry element | Defatted rice bran. |
| 650 #0 - Subject-Topical Term | |
| Topical term or geographic name entry element | Lipase. |
| 650 #0 - Subject-Topical Term | |
| Topical term or geographic name entry element | Phenolic compound. |
| 700 1# - Added Entry-Personal Name | |
| Name | Lai, Jia-Ying. |
| 700 1# - Added Entry-Personal Name | |
| Name | Liao, Jie-Ann. |
| 700 1# - Added Entry-Personal Name | |
| Name | Sung, Jih-Min. |
| 700 1# - Added Entry-Personal Name | |
| Name | Lin, Sheng-Dun. |
| 773 ## - Host Item Entry | |
| Title | Cereal Chemistry |
| Related parts | 95(1)2018:167-176 |
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