In vitro inhibition of lipase, a-amylase, a-glucosidase, and angiotensin-converting enzyme by defatted rice bran extracts of red-pericarp rice mutant / (Record no. 148309)

MARC details
000 -LEADER
fixed length control field 02888nab a22002657a 4500
850 ## - HOLDING INSTITUTION
Holding institution เอกสารภาษาไทย (ชั้น 5)
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190122b xxu||||| |||| 00| 0 eng d
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Repr.F18
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Chiou, Shiow-Ying.
245 10 - TITLE STATEMENT
Title In vitro inhibition of lipase, a-amylase, a-glucosidase, and angiotensin-converting enzyme by defatted rice bran extracts of red-pericarp rice mutant /
author Shiow-Ying Chiou ... [et.al.].
500 ## - GENERAL NOTE
GENERAL NOTE สนใจติดต่อขอรับบริการเอกสารฉบับเต็มที่ one stop service (สำนักหอสมุดฯ) หรือ e-mail ([email protected]) โทร. 0 2201 7254-56, 0 2201 7287-89 (จัดเก็บชั้น 5 - Repr.F18)
518 ## - Year/Month of cataloging
Year/Month YJ2019 M02
520 ## - SUMMARY, ETC.
Summary, etc. Background and objectives Freeze‐dried aqueous and various ethanolic (25%, 50%, 75%, and 95%) extracts of defatted red rice (mutant AM‐425) bran were prepared and designated as E0, E25, E50, E75, and E95, respectively. Phenolic constituents of extracts and the in vitro inhibitory effects of extracts against lipase, α‐amylase, α‐glucosidase, and angiotensin‐converting enzyme (ACE) were examined. Findings Yields of extracts ranged from 16.45% (E0) to 11.57% (E95). The E50 and E75 had higher total phenols (79.2-80.9 mg ferulic acid equivalent (FAE)/g extract) than other extracts. The E75 and E95 had higher total flavonoids (20.46-21.35 mg catechin equivalent/g extract). The most abundant phenolic acid and flavonoid were ferulic acid and catechin, respectively. Both E50 and E75 had higher inhibitory activity against lipase (IC50, 35.95-35.97 mg/ml), α‐amylase (IC50, 21.99-22.02 mg/ml), α‐glucosidase (IC50, 1.67 mg/ml), and ACE (IC50, 2.93-2.97 mg/ml). Conclusions Both E50 and E75 can be used to produce high‐value functional supplements. However, further studies with in vivo models reflecting potential human benefits are needed in the future. Significance and novelty The tested E50 and E75 had higher contents of total phenols. Moreover, both E50 and E75 were able to inhibit key enzymes relevant to obesity (lipase), type‐2 diabetes mellitus (α‐amylase and α‐glucosidase), and hypertension (angiotensin‐converting enzyme) in an in vitro model. The results suggest that defatted rice bran extracts could be considered as potential candidates for developing functional foods or supplements.
648 ## - SUBJECT ADDED ENTRY--CHRONOLOGICAL TERM
Chronological term FOOD62M01
650 #0 - Subject-Topical Term
Topical term or geographic name entry element Angiotensin-converting enzyme.
650 #0 - Subject-Topical Term
Topical term or geographic name entry element Defatted rice bran.
650 #0 - Subject-Topical Term
Topical term or geographic name entry element Lipase.
650 #0 - Subject-Topical Term
Topical term or geographic name entry element Phenolic compound.
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Name Lai, Jia-Ying.
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Name Liao, Jie-Ann.
700 1# - Added Entry-Personal Name
Name Sung, Jih-Min.
700 1# - Added Entry-Personal Name
Name Lin, Sheng-Dun.
773 ## - Host Item Entry
Title Cereal Chemistry
Related parts 95(1)2018:167-176
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Source of classification or shelving scheme
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